5-Amino-1MQ is a metabolism-focused small molecule used to explore how tweaking cellular NAD⁺ handling can impact fat mass, energy expenditure, and insulin sensitivity. It’s a favorite in the metabolic lab world for studying the intersection of obesity, mitochondrial function, and cellular energetics.
How It Works
5-Amino-1MQ inhibits nicotinamide N-methyltransferase (NNMT), an enzyme that consumes nicotinamide and reduces its availability for conversion into NAD⁺. Inhibiting NNMT can increase NAD⁺ levels, which enhances activities of NAD⁺-dependent enzymes like sirtuins and potentially improves mitochondrial function and fat oxidation. Preclinical data suggest reductions in adipocyte size and improved metabolic profiles.
Regulatory & Research Note
5-Amino-1MQ is not approved by the FDA for any medical indication. It is supplied for laboratory research only and is not for human use.

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