KPV is the anti-inflammatory micro-peptide researchers love for gut, skin, and immune studies. It’s tiny, potent, and designed to calm inflammatory chaos without broadly suppressing the immune system.
How It Works
KPV (Lys-Pro-Val) is a C-terminal fragment of alpha-MSH and interacts with melanocortin receptors, particularly MC1R and MC3R. It downregulates NF-κB and pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6, while supporting epithelial barrier integrity in gut and skin models. The result is a targeted anti-inflammatory effect with barrier support.
Regulatory & Research Note
KPV is not approved by the FDA as a drug. It is available exclusively for research use and is not for human ingestion or injection.
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